解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Global emergence of Gram-negative bacteria carrying the plasmid-borne resistance genes, blaMBL and mcr, raises a significant challenge to the treatment of life-threatening infections by the antibiotics, carbapenem and colistin (COL). Here, we identify an antirheumatic drug, auranofin (AUR) as a dual inhibitor of metal...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18939-y
更新日期:2020-10-16 00:00:00
abstract::The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, dev...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/s41467-020-19045-9
更新日期:2020-10-16 00:00:00
abstract::Metal halide perovskites feature crystalline-like electronic band structures and liquid-like physical properties. The crystal-liquid duality enables optoelectronic devices with unprecedented performance and a unique opportunity to chemically manipulate the structure with low energy input. In this work, we leverage the...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19009-z
更新日期:2020-10-16 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-020-19222-w
更新日期:2020-10-16 00:00:00
abstract::During neuronal differentiation, the transcriptional profile and the epigenetic context of neural committed cells is subject to significant rearrangements, but a systematic quantification of global histone modification changes is still missing. Here, we show that H3K79me2 increases and H3K27ac decreases globally durin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19001-7
更新日期:2020-10-15 00:00:00
abstract::Winter Eurasian cooling after the mid-1990s has been verified by numerous studies, although in recent decades, the mid-latitudes of the Northern Hemisphere have been rapidly warming globally. Because the cooling is not uniform at different spatial and temporal scales, over time, this change may not truly reflect the n...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19014-2
更新日期:2020-10-15 00:00:00
abstract::Polyborylated organic compounds have been emerging as versatile building blocks in chemical synthesis. Here we report a selective cobalt-catalyzed deoxygenative 1,1,3-triborylation reaction of allylic ethers with pinacolborane to prepare 1,1,3-triborylalkane compounds. With naturally abundant and/or synthetic cinnamic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19039-7
更新日期:2020-10-15 00:00:00
abstract::Fear conditioning is a form of associative learning that is known to involve different brain areas, notably the amygdala, the prefrontal cortex and the periaqueductal grey (PAG). Here, we describe the functional role of pathways that link the cerebellum with the fear network. We found that the cerebellar fastigial nuc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18953-0
更新日期:2020-10-15 00:00:00
abstract::The most frequent genetic alterations across multiple human cancers are mutations in TP53 and the activation of the PI3K/AKT pathway, two events crucial for cancer progression. Mutations in TP53 lead to the inhibition of the tumour and metastasis suppressor TAp63, a p53 family member. By performing a mouse-human cross...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18973-w
更新日期:2020-10-14 00:00:00
abstract::Manipulating symmetry environments of metal ions to control functional properties is a fundamental concept of chemistry. For example, lattice strain enables control of symmetry in solids through a change in the nuclear positions surrounding a metal centre. Light-matter interactions can also induce strain but providing...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18869-9
更新日期:2020-10-14 00:00:00
abstract::Parkinson's disease-associated kinase LRRK2 has been linked to IFN type II (IFN-γ) response in infections and to dopaminergic neuronal loss. However, whether and how LRRK2 synergizes with IFN-γ remains unclear. In this study, we employed dopaminergic neurons and microglia differentiated from patient-derived induced pl...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18755-4
更新日期:2020-10-14 00:00:00
abstract::Akin to single-site homogeneous catalysis, a long sought-after goal is to achieve reaction site precision in heterogeneous catalysis for chemical control over patterns of activity, selectivity and stability. Herein, we report on metal phosphides as a class of material capable of realizing these attributes and unlock t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18943-2
更新日期:2020-10-13 00:00:00
abstract::Modern geophysics highlights that the slip behaviour response of faults is variable in space and time and can result in slow or fast ruptures. However, the origin of this variation of the rupture velocity in nature as well as the physics behind it is still debated. Here, we first highlight how the different types of f...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18937-0
更新日期:2020-10-12 00:00:00
abstract::Zinc finger E-box binding homeobox 1 (Zeb1) has been demonstrated to participate in the acquisition of the properties of cancer stem cells (CSCs). However, it is largely unknown how signals from the tumor microenvironment (TME) contribute to aberrant Zeb1 expression. Here, we show that Zeb1 depletion suppresses stemne...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18860-4
更新日期:2020-10-12 00:00:00
abstract::The COVID-19 epidemic hit Italy particularly hard, yielding the implementation of strict national lockdown rules. Previous modelling studies at the national level overlooked the fact that Italy is divided into administrative regions which can independently oversee their own share of the Italian National Health Service...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18827-5
更新日期:2020-10-09 00:00:00
abstract::Modern beam shaping techniques have enabled the generation of optical fields displaying a wealth of structural features, which include three-dimensional topologies such as Möbius, ribbon strips and knots. However, unlike simpler types of structured light, the topological properties of these optical fields have hithert...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18792-z
更新日期:2020-10-09 00:00:00
abstract::Six CO2 fixation pathways are known to operate in photoautotrophic and chemoautotrophic microorganisms. Here, we describe chemolithoautotrophic growth of the sulphate-reducing bacterium Desulfovibrio desulfuricans (strain G11) with hydrogen and sulphate as energy substrates. Genomic, transcriptomic, proteomic and meta...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18906-7
更新日期:2020-10-09 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-020-19127-8
更新日期:2020-10-09 00:00:00
abstract::Although substantial progress has been made in cancer biology and treatment, clinical outcomes of bladder carcinoma (BC) patients are still not satisfactory. The tumor microenvironment (TME) is a potential target. Here, by single-cell RNA sequencing on 8 BC tumor samples and 3 para tumor samples, we identify 19 differ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18916-5
更新日期:2020-10-08 00:00:00
abstract::Tibetan wheat is grown under environmental constraints at high-altitude conditions, but its underlying adaptation mechanism remains unknown. Here, we present a draft genome sequence of a Tibetan semi-wild wheat (Triticum aestivum ssp. tibetanum Shao) accession Zang1817 and re-sequence 245 wheat accessions, including w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18738-5
更新日期:2020-10-08 00:00:00
abstract::The evolutionary progression from primary to metastatic prostate cancer is largely uncharted, and the implications for liquid biopsy are unexplored. We infer detailed reconstructions of tumor phylogenies in ten prostate cancer patients with fatal disease, and investigate them in conjunction with histopathology and tum...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18843-5
更新日期:2020-10-08 00:00:00
abstract::COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral drugs or vaccines were developed against the closely related coronavirus, SARS-CoV-1 or MERS-CoV, despite previous zoonotic outbreaks. To identify starting points for such therapeutics, we performed a large-scale screen of electro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18709-w
更新日期:2020-10-07 00:00:00
abstract::Epilepsy is one of the most common neurological disorders, yet its pathophysiology is poorly understood due to the high complexity of affected neuronal circuits. To identify dysfunctional neuronal subtypes underlying seizure activity in the human brain, we have performed single-nucleus transcriptomics analysis of >110...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18752-7
更新日期:2020-10-07 00:00:00
abstract::Selenium cathodes have attracted considerable attention due to high electronic conductivity and volumetric capacity comparable to sulphur cathodes. However, practical development of lithium-selenium batteries has been hindered by the low selenium reaction activity with lithium, high volume changes and rapid capacity f...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18820-y
更新日期:2020-10-06 00:00:00
abstract::The social intelligence hypothesis (SIH) posits that within-group interactions drive cognitive evolution, but it has received equivocal support. We argue the SIH overlooks a major component of social life: interactions with conspecific outsiders. Competition for vital resources means conspecific outsiders present myri...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/s41467-020-18780-3
更新日期:2020-10-06 00:00:00
abstract::Human gut microbiome is a promising target for managing type 2 diabetes (T2D). Measures altering gut microbiota like oral intake of probiotics or berberine (BBR), a bacteriostatic agent, merit metabolic homoeostasis. We hence conducted a randomized, double-blind, placebo-controlled trial with newly diagnosed T2D patie...
journal_title:Nature communications
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41467-020-18414-8
更新日期:2020-10-06 00:00:00
abstract::Determining nanoscale protein distribution via Photoactivated Localization Microscopy (PALM) mandates precise knowledge of the applied fluorophore's blinking properties to counteract overcounting artifacts that distort the resulting biomolecular distributions. Here, we present a readily applicable methodology to deter...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18726-9
更新日期:2020-10-05 00:00:00
abstract::To perform their computational function, genetic circuits change states through a symphony of genetic parts that turn regulator expression on and off. Debugging is frustrated by an inability to characterize parts in the context of the circuit and identify the origins of failures. Here, we take snapshots of a large gen...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18630-2
更新日期:2020-10-05 00:00:00
abstract::Nonequilibrium atomic structures can host exotic and technologically relevant properties in otherwise conventional materials. Oxygen octahedral rotation forms a fundamental atomic distortion in perovskite oxides, but only a few patterns are predominantly present at equilibrium. This has restricted the range of possibl...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18741-w
更新日期:2020-10-02 00:00:00
abstract::Acoustic communication is enabled by the evolution of specialised hearing and sound producing organs. In this study, we performed a large-scale macroevolutionary study to understand how both hearing and sound production evolved and affected diversification in the insect order Orthoptera, which includes many familiar s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18739-4
更新日期:2020-10-02 00:00:00
abstract::Zika virus (ZIKV) is an emerging mosquito borne flavivirus and a major public health concern causing severe disease. Due to the presence of a lipid membrane and structural heterogeneity, attaining an atomic resolution structure is challenging, but important to understand virus assembly and life cycle mechanisms that o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18747-4
更新日期:2020-10-02 00:00:00
abstract::In order to control and eradicate epidemic cholera, we need to understand how epidemics begin, how they spread, and how they decline and eventually end. This requires extensive sampling of epidemic disease over time, alongside the background of endemic disease that may exist concurrently with the epidemic. The unique ...
journal_title:Nature communications
pub_type: 历史文章,杂志文章
doi:10.1038/s41467-020-18647-7
更新日期:2020-10-01 00:00:00
abstract::Despite highly promising characteristics of three-dimensionally (3D) nanostructured catalysts for the oxygen evolution reaction (OER) in polymer electrolyte membrane water electrolyzers (PEMWEs), universal design rules for maximizing their performance have not been explored. Here we show that woodpile (WP)-structured ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18686-0
更新日期:2020-10-01 00:00:00
abstract::Preparation and characterization of polariton Bose-Einstein condensates in micro-cavities of high quality are at the frontier of contemporary solid state physics. Here, we report on three-dimensional polariton condensation and confinement in pseudo-spherical ZnO microcrystals. The boundary of micro-spherical ZnO resem...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18666-4
更新日期:2020-09-30 00:00:00
abstract::Identification of the complete set of translated genes of viruses is important to understand viral replication and pathogenesis as well as for therapeutic approaches to control viral infection. Here, we use chemical proteomics, integrating bio-orthogonal non-canonical amino acid tagging and high-resolution mass spectr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18718-9
更新日期:2020-09-29 00:00:00
abstract::Myelin, rather than being a static insulator of axons, is emerging as an active participant in circuit plasticity. This requires precise regulation of oligodendrocyte numbers and myelination patterns. Here, by devising a laser ablation approach of single oligodendrocytes, followed by in vivo imaging and correlated ult...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18632-0
更新日期:2020-09-29 00:00:00
abstract::Chemical synthesis of amino acids from renewable sources is an alternative route to the current processes based on fermentation. Here, we report visible-light-driven amination of biomass-derived α-hydroxyl acids and glucose into amino acids using NH3 at 50 °C. Ultrathin CdS nanosheets are identified as an efficient an...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18532-3
更新日期:2020-09-29 00:00:00
abstract::Somatic mutations in the calreticulin (CALR) gene are associated with approximately 30% of essential thrombocythemia (ET) and primary myelofibrosis (PMF). CALR mutations, including the two most frequent 52 bp deletion (del52) and 5 bp insertion (ins5), induce a frameshift to the same alternative reading frame generati...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18691-3
更新日期:2020-09-28 00:00:00
abstract::Integrating and manipulating the nano-optoelectronic properties of Van der Waals heterostructures can enable unprecedented platforms for photodetection and sensing. The main challenge of infrared photodetectors is to funnel the light into a small nanoscale active area and efficiently convert it into an electrical sign...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18544-z
更新日期:2020-09-25 00:00:00
abstract::The atypical chemokine receptor 3 (ACKR3) plays a pivotal role in directing the migration of various cellular populations and its over-expression in tumors promotes cell proliferation and invasiveness. The intracellular signaling pathways transducing ACKR3-dependent effects remain poorly characterized, an issue we add...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18634-y
更新日期:2020-09-25 00:00:00